Fort Lafayette, sometimes called Fort Fayette, (1792–1814) was an American fort in Pittsburgh, Pennsylvania, United States.
It was sited near present-day Penn Avenue and Ninth Street in the Cultural District of Downtown Pittsburgh.
Following the American Revolutionary War, hostilities continued between the Indians and Americans in Western Pennsylvania. In 1784 the new federal government mounted a failed expedition against the Indians. Again in 1790 and 1791 two successive campaigns also failed.
This perceived threat prompted the government in 1792 to build Fort Lafayette in Pittsburgh, to replace Fort Pitt, as a supply center for Fort McIntosh, located down stream on the Ohio River. An army led by General Anthony Wayne eventually defeated in 1794 the Ohio Indians near modern Toledo, Ohio at the Battle of Fallen Timbers, thus ending tensions in the region.